THROMBOSIS AND HEMOSTASIS Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach
نویسندگان
چکیده
1Inserm, Unite Mixte de Recherche (UMR) S937, Paris; 2Université Pierre et Marie Curie, Université Paris 06, UMR S937, Paris; 3Commissariat à l’Energie Atomique, Institut de Génomique, Centre National de Génotypage, Evry; 4Inserm, UMR S626, Marseille; Université de la Méditerranée, Marseille; 5Laboratoire d’Hématologie, Centre Hospitalier Universitaire (CHU) Montpellier, Montpellier; 6Service de Médecine Vasculaire, CHU Grenoble, Grenoble; 7UMR U557, Inserm U1125, Institut National de Ia Recherche Agronomique/Caisse Nationale d’Assurance Maladie Paris, Université Paris, Paris; and 8Inserm U765, Médecine Vasculaire-Hypertension, Hôpital Européen Georges-Pompidou, Université Paris-Descartes, Paris, France
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Thrombophilia is defined as a disorder of hemostasis in which there is a tendency for the occurrence of thrombosis in veins or arteries due to abnormalities in blood composition, blood flow, or the vascular wall. The pathogenesis of venous versus arterial thrombosis is very distinct and these are often considered as separate diseases. The term thrombophilia is most often used in combination wit...
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